端粒酶是一种RNA-蛋白复合体,以其RNA为模板,以端粒3′末端为引物,合成端粒重复序列。端粒酶活性的激活是阻止端粒重复序列缩短并使细胞获得永生性的必要途径。研究表明人类正常组织细胞除生殖细胞、一些淋巴细胞和造血于细胞外,端粒酶都不具有活性,而90％以上的肿瘤细胞端粒酶都有活性,端粒酶的激活与肿瘤细胞的发生、转移有密切关系。因此,了解端粒酶在永生性细胞中的变化规律及其调节机制,对肿瘤的诊断和治疗有着十分重要的意义。本 Telomerase is an RNA-protein complex that uses its RNA as a template and telomeric 3 ’ends as primers to synthesize telomeric repeat sequences. Activation of telomerase activity is a necessary way to prevent shortening of telomeric repeat sequences and to obtain immortality of cells. Studies have shown that human normal tissue cells in addition to germ cells, some lymphocytes and hematopoietic extracellular, telomerase are not active, and more than 90% of telomerase tumor cells are active, the activation of telomerase and tumor cells Occurrence, transfer is closely related. Therefore, to understand the changes of telomerase in immortalized cells and its regulatory mechanism, the diagnosis and treatment of cancer has a very important significance. this