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采用开放对比研究比较硫酸依替米星 (ETM)与奈替米星 (NTL)以评价 ETM治疗下呼吸道感染的疗效和安全性。选择未用过抗生素治疗或虽用抗菌药物但无效的下呼吸道感染的住院病人 6 4例 ,随机分成两组 ,分别给 ETM或 NTL。结果显示 ,ETM与 NTL的有效率分别为 87.5 % (2 8/ 32 )及 90 .6 % (2 9/ 32 ) ,细菌清除率为 87.5 % (2 1/ 2 4)与 83.33% (2 0 / 2 4) ,不良反应发生率为 6 .2 5 % (2 / 32 )与 3.12 % (1/ 32 )。两组比较差异均无显著性。提示 ETM与 NTL相仿 ,抗菌谱广 ,疗效好 ,不良反应少 ,对下呼吸道感染有效且安全。
An open comparison study comparing etimicin sulfate (ETM) with netilmicin (NTL) was performed to evaluate the efficacy and safety of ETM in the treatment of lower respiratory tract infections. Sixty-four inpatients with lower respiratory tract infection that had not been treated with antibiotics or who were ineffective with antibiotics were randomized to ETM or NTL. The results showed that the effective rates of ETM and NTL were 87.5% (2/32) and 90.6% (29/32) respectively, and the bacterial clearance rates were 87.5% (21/24) and 83.33% (20% / 2 4), adverse reactions were 6.52% (2/32) and 3.12% (1/32). There was no significant difference between the two groups. Tip ETM and NTL similar broad antibacterial spectrum, good efficacy, fewer adverse reactions, effective and safe for lower respiratory tract infection.