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目的 :为了解麻疹—腮腺炎—风疹疫苗初免效果 ,探讨其免疫程序。方法 :对 8月龄婴儿用MMRⅡ疫苗初免 ,16月龄时用S79株冻干流行性腮腺炎活疫苗再免。用血凝抑制 (HI)试验测麻疹、腮腺炎和风疹抗体。结果 :易感儿初免后 1月麻疹、腮腺炎和风疹HI抗体阳转率和GMRT分别为 10 0 %和 5 6 6 3± 2 0 5 ,7 5 5 %和 1 10± 1 43以及 97 83%和 183 77± 4 0 2 ;8个月后腮腺炎抗体阳转率和GMRT分别升至 43 48%和 1 72± 2 0 6。腮腺炎疫苗再免成功率和GMRT分别为 86 96 %和 7 5 3± 3 32。结论 :8月龄MMR疫苗初免对麻疹和风疹有良好的免疫效果 ,对腮腺炎效果较差 ,但用腮腺炎疫苗再免后仍可获良好的免疫效果 ;可以选用 8月龄MMR疫苗初免和 15月龄后腮腺炎疫苗再免的免疫程序。
Objective: To understand the measles-mumps-rubella vaccine initial effect, to explore its immunization program. Methods: The 8-month-old infants were immunized with MMRⅡ vaccine, and the 16-month old mice were re-treated with S79 lyophilized mumps live vaccine. Measles, mumps and rubella antibodies were tested with the hemagglutination inhibition (HI) test. Results: The positive rates of gynecological measles, mumps and rubella HI antibodies and GMRT were 100% and 563 ± 205, 75% and 110 ± 1 43 and 97 83% and 183 77 ± 420. After 8 months, the mumps antibody positive rate and GMRT increased to 43 48% and 1 72 ± 2 0 6, respectively. Mumps vaccine re-free success rate and GMRT were 86 96% and 73 3 3 32 respectively. CONCLUSION: The 8-month-old MMR vaccine has good immunization effect on measles and rubella and poor efficacy on mumps, but good immunization effect can still be obtained after mumps vaccine re-avoidance. The 8-month-old MMR vaccine can be used initially Free and 15 months after the mumps vaccine re-immunization program.