【摘 要】
：
No-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA) was synthesized viaa multistep procedure from a commercial available precursor, 6-nitroveratraldehydc.The total
【机 构】
：
Center of Radiopharmaceutical Research,Nanfang PET Center
论文部分内容阅读
No-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA) was synthesized viaa multistep procedure from a commercial available precursor, 6-nitroveratraldehydc.The total synthesis time was 75min, with a radiochemical yield of (10±3)%, highradiochemical purity (＞99%) and high enantiomeric purity (＞95%). The biodistri-butions of 6-FDOPA in normal and unilateral PD model rats were measured. Theresults from normal rats showed the expected high concentration of radioactivity instriatum and low distributions in cerebrum, cortex and cerebellum. The ratio of theradioactivity in striatum to cerebellum reached a peak value (5.9) at 60 min. In uni-lateral PD model rats, whose substania nigra of the right side had been damaged bypre-treated with 6-OHDA, the radioactive concentration in striatum of the damagedside was significantly lower than that of the undamaged side or that of both sides instriatum of control groups.
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