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作者对美国大达特拉华州地区1970～1979年确诊的104例神经母细胞瘤患者进行一项产前危险因素配对病例对照研究。这种交感神经系统胚胎肿瘤,占美国最常见儿童肿瘤的第4位,且在婴儿期才被确诊,与其他肿瘤一样,治疗效果令人非常失望。作者认为,胎儿在母亲子宫体内必定受到体外危险因素的影响。因而,其病因因素的研究,应针对患儿出生前父母接触的危险因素。研究发现,与对照组母亲相比,患儿母亲在妊娠期接触下列因素者,患神经母细胞瘤的危险性增加。①妊娠期服用神经活性药物,与对照组的差比
The authors performed a paired case-control study of prenatal risk factors in 104 neuroblastoma patients diagnosed in the Greater Detroit area of 1970-79. This sympathetic nervous system embryonic tumor, which accounts for the fourth most common childhood tumor in the United States, was diagnosed only in infancy and, like other tumors, was very disappointing. The authors believe that the fetus in the mother’s uterus must be subject to in vitro risk factors. Therefore, the etiological factor of the study, should be targeted at the risk of exposure to the parents of the child before birth. The study found that, compared with mothers in the control group, mothers with children exposed to the following factors during pregnancy, increased risk of neuroblastoma. ① taking gemcitabine during pregnancy, the difference between the control group