我们首先研究了聚酪氨酰明胶,证明酪氨酰化确实能增加明胶的免疫原性。继Humphrey之后又研究了苄氧碳基酪氨酰carbobenztloxytyrosyl)明胶,并因此制备出我们的第一个合成抗原(T,G)-A-L,它是一个支链多氨基酸,其中L-酪氨酸和L-谷氨酸附着于聚丙氨酸的侧链上,而后者又附着于聚赖氨酸的骨架结构。第一种抗原的合成,使我们能够合成数十种类似的抗 We first studied polytyrosyl gelatin to demonstrate that tyrosylation actually increases the immunogenicity of gelatin. Following Humphrey, benzyloxycarbonylazyltyrosyl) gelatin was also studied and thus our first synthetic antigen (T, G) -AL was prepared, which is a branched polyamino acid in which L-tyrosine L-glutamic acid is attached to the side chain of polyalanine, which in turn is attached to the framework of polylysine. The synthesis of the first antigen allows us to synthesize dozens of similar antigens