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目的:制备氨甲喋吟(methotrexate,MTX)、铁磁性微球(ferromagnetic microspheres,FMS),探讨工艺条件对成球的影响,并测定微球的粒径,磁性物质和药物的含量以及药物释放度等主要物理性质.方法:以人血白蛋白(Humanserum albumin,HSA)作载体,磁铁粉作磁响应物质,用加热固化法制备抗肿瘤药物MTX的磁性微球,显微镜下现察微球形态大小,计算粒径分布,重量法测定磁性物质的含量,紫外分光光度法测定MTX含量及体外释放度.结果:控制工艺条件可得粒径20～60μm为主,Fe_3O_4含量为61.90%～64.57%,MTX含量8.30%～9.11%,且具有一定缓释性能的磁性微球(FMS).控制固化时间可以改变微球的释放性能.结论:自制的FMS符合临床使用要求,有希望作为新型药物载体用于靶向给药系统.
OBJECTIVE: To prepare methotrexate (MTX) and ferromagnetic microspheres (FMS) to investigate the effect of technological conditions on the formation of spheres. The particle size, content of magnetic substance and drug, and drug release Degree and other major physical properties.Methods: Human serum albumin (HumanA albumin, HSA) as a carrier, magnet powder as a magnetic response substance, the use of heat curing method for the preparation of anti-tumor drug MTX magnetic microspheres microspheres morphology Size, particle size distribution, the content of magnetic substance by gravimetric method and the MTX content and the in vitro release degree by UV spectrophotometry.Results: The particle size of 20 ~ 60μm and the content of Fe_3O_4 were 61.90% -64.57% , The content of MTX was 8.30% ~ 9.11%, and some sustained-release magnetic microspheres (FMS) were obtained.Controlling the curing time could change the release properties of the microspheres.Conclusion: The homemade FMS is suitable for clinical use and promising as a new drug carrier For targeted drug delivery systems.