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目的:观察不同治法方药对2型糖尿病胰岛素抵抗(IR)大鼠细胞因子的影响。方法:以高脂饲料喂养加小剂量链脲佐菌素(STZ)ip的方法建立2型糖尿病IR大鼠模型。给予不同治法的方药干预。测定空腹血糖(FPG)、血清胰岛素(Fins)、血清瘦素(Leptin)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的含量,并计算胰岛素敏感指数(ISI)。结果:中药干预Ⅰ方(益气养阴化痰活血方)、Ⅱ方(益气养阴化痰降浊方)均明显降低模型大鼠FPG和Fins水平,提高ISI,使模型大鼠升高的血清Leptin,TNF-α含量显著降低。结论:中药干预Ⅰ方(益气养阴化痰活血方)在不同治法的方药中治疗作用最优。益气养阴化痰活血方、益气养阴化痰降浊方对2型糖尿病胰岛素抵抗大鼠的糖、脂改善作用可能与其降低血清细胞因子水平有关。
Objective: To observe the effects of different prescriptions on cytokines in type 2 diabetic rats with insulin resistance (IR). Methods: Type 2 diabetic rat model was established by feeding high fat diet with low dose streptozotocin (STZ) ip. Give different prescriptions for interventions. The levels of fasting blood glucose (FPG), serum insulin (Fins), serum leptin, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured and insulin sensitivity index (ISI) . Results: The traditional Chinese medicine intervention Ⅰ (Yiqi Yangyin Huatan Huoxue Fang), Ⅱ Fang (Yiqi Yangyin phlegm Jiangzhuo Fang) significantly reduced FPG and Fins levels in model rats, increased ISI, the model rats increased Serum Leptin, TNF-α content was significantly reduced. Conclusion: The traditional Chinese medicine prescription Ⅰ (Yiqi Yangyin Huatan Huoxue prescription) in the treatment of different prescriptions of the best treatment. Yiqi Yangyin Huatan Huoxue Fang, Yiqi Yangyin Huatanjiangzhuo decoction on type 2 diabetes rats with insulin resistance may be related to its role in reducing serum levels of cytokines.