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目的：研究食管癌患者手术前后血清脑肠肽变化．方法：用放射免疫法测定23例中晚期食管瘤患者手术前后血清P物质（SP），β-内啡肽（β-EP），血管活性肠肽（VIP），胃功素（MTL），促胃液素（GT）和亮脑啡肽（LEK）含量，并以27例相当的正常人作对照．结果：食管瘤患者血清SP（pmol／L，88．2±54．9vs38．7±20．9，P＜0．01），β－EP（ng／L，61．9±26．6vs36．6±20．8，P＜0．05），含量显著高于正常人，而血清GT（ng／L，36．7±23．3vs61．0±22．5,P＜0，05）含量则显著低于正常人，且血清SP，β-EP升高和GT降低呈正相关（P＜0．05）；血清SP，β-EP升高与GT降低各呈正相关（γ值分别为0．462，0．459，P值均＜0．05）．21例术后2mo检查血清SP，β-EP和GT，结果与术前比较仅β-EP（ng／L，40．4±16．2，P＜0．05）降低，SP和GT无明显变化（P＞0．05）．结论：晚期食管癌患者血清脑肠肽类物质可发生变化，且存在一定相关性，术后仅β-EP降下．联合测定血清这些物质对研究食管癌患者脑肠肽类变化有一定意义．
Objective: To study the changes of serum brain-gut peptides in patients with esophageal cancer before and after surgery. METHODS: Serum SP (substance P), β-endorphin (β-EP), vasoactive intestinal peptide (VIP), and gastric tocopherol (MTL) were measured by radioimmunoassay in 23 patients with advanced esophageal tumor before and after surgery. Gastrin (GT) and Leu-enkephalin (LEK) content were compared with 27 normal controls. Results: Serum SP of patients with esophageal tumor (pmol/L, 88.2±54.9 vs 38.7±20.9, P<0.01), β-EP (ng/L, 61.9±26.6 vs 36. 6±20.8, P<0.05), the content was significantly higher than normal, and serum GT (ng/L, 36.7±23.3 vs 61.0±22.5, P<0,05) Significantly lower than normal, serum SP, β-EP increased and GT decreased were positively correlated (P<0.05); serum SP, β-EP increased and GT decreased were positively correlated (γ values were 0.462 respectively , 0.459, P value <0.05). Serum SP, β-EP, and GT were examined at 21 months after surgery. The results showed that only β-EP (ng/L, 40.4±16.2, P<0.05) decreased compared with preoperative, and SP and GT were not significantly different. Change (P>0.05). Conclusion: The serum brain-intestine peptides in patients with advanced esophageal cancer may change, and there is a certain correlation, only β-EP is decreased after surgery. Combined determination of these substances in serum has a certain significance for the study of changes of brain-gut peptides in patients with esophageal cancer.