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T细胞受体 (TCR )对特异性肽 MHC复合物的识别是产生适应性免疫应答的关键步骤。因此 ,TCR介导的对T细胞活化抑制的拮抗作用可望成为一种特异性强而几乎没有副作用的免疫干预机制。本文拟就TCR拮抗作用机制及其医学意义的研究做一简单综述
Recognition of specific peptide MHC complexes by T cell receptors (TCRs) is a key step in generating an adaptive immune response. Therefore, TCR-mediated antagonism of T cell activation inhibition is expected to become a kind of immune intervention mechanism with strong specificity and few side effects. This article intends to make a brief review on the mechanism of TCR antagonism and its medical significance