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本文报告了同时检测21例全身性红斑狼疮病人CH50与ACH50的情况,发现病人补体第一途径和第二途径的溶血活性明显低于正常对照,尤以CH50为著。两者的相关系数r为0.52。由此推断,在SLE的发病机制中不仅有补体第一途径成份的消耗,且有第二途径的参与。 SLE时补体活性降低的程度与疾病的重笃程度成平行的关系。伴有肾功能受损者降低尤甚。CH50与ACH50明显低下者,对激素与免疫抑制剂治疗的反应较差,预后不佳。因此,临床上同时检测CH50及ACH50在辅助诊断及预后判断上有一定意义,
This article reports the simultaneous detection of CH50 and ACH50 in 21 patients with systemic lupus erythematosus and found that the hemolytic activity of the first and second pathway of complement was significantly lower than that of the normal control, especially CH50. The correlation coefficient r between the two is 0.52. It is concluded that in the pathogenesis of SLE not only the consumption of the first component of complement, and there is a second way to participate. The extent of diminished complement activity in SLE parallels the importance of disease. Accompanied by impaired renal function decreased particularly. CH50 and ACH50 significantly lower, the response of hormones and immunosuppressive therapy is poor, the prognosis is poor. Therefore, the clinical simultaneous detection of CH50 and ACH50 in the diagnosis and prognosis of adjuvant have some significance,