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目的:探讨桃红四物丸对兔自体皮片移植术后皮片成活及VEGFR-2表达的影响。方法:将40只新西兰大白兔随机分为两组,均进行皮片移植手术造模,通过血管密度检测和免疫组化染色的方法,观察两组术后5d和8d皮片血管密度及VEGFR-2的表达情况,并加以比较。结果:治疗组在术后5d和8d均有较高的血管密度及VEGFR-2积分光密度值,其值均高于对照组,差异均有统计学意义(P<0.05)。结论:桃红四物丸对兔自体皮片移植术后皮片成活及VEGFR-2的表达有促进作用。
Objective: To investigate the effect of Taohongsiwu pill on survival of dermis and expression of VEGFR-2 after autologous skin grafting in rabbits. Methods: Forty New Zealand white rabbits were randomly divided into two groups. All of them were treated by skin graft. The vascular density and immunohistochemical staining were used to observe the changes of vascular density and VEGFR- 2 of the expression, and to be compared. Results: The treatment group had higher vessel density and integral optical density of VEGFR-2 on the 5th and 8th day postoperatively, both of which were significantly higher than those of the control group (P <0.05). Conclusion: Taohongsiwu pill can promote the survival of dermis and the expression of VEGFR-2 after autologous skin grafting in rabbits.