【摘 要】
：
As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pill
【机 构】
：
State Key Laboratory of Chemical Engineering,Key Laboratory of Excited-State Materials of Zhejiang P
论文部分内容阅读
As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results.Owing to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional biomaterials.On one hand,pillararenes can either be used individually or form di-versiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of drugs.On the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability.In this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/che-motherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,etc.By introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are described.Future challenges and directions of this field are also outlined.
其他文献
Hydrosilylation is one of the most important reactions in synthetic chemistry and ranks as a fundamental method to access organosilicon compounds in industrial and academic processes.However,the enantioselective construction of chiral-at-silicon compounds
The development of nanomedicine systems for applications in cancer therapies has been widely explored in the last decade.With inherent biocompatibility,nanomedicine devices derived from biological membranes have shown many unique advantages compared with
Carbon nanohoop,a class of constrained molecular architecture consisting of linked arene units,has attracted considerable interest from both experimental and theoretical chemists due to its synthetic challenge and aesthetic architectures.Another fascinati
Ultralong organic room-temperature phosphorescence (RTP) materials have attracted tremendous attention recently due to their diverse applications.Several ultralong organic RTP materials mimicking the host-guest architecture of inorganic systems have been
The design of efficient iron-based catalysts remains a great challenge for selective cyclohexane oxidation to cyclohexanone under mild conditions.Because of the complex distribution of iron location on the support,the selectivity is always low.Here,we rep
The regulated crystallization of perovskite and highly repeatable preparation are decisive challenges for large-scale flexible perovskite solar cells (PSCs).Herein,we synthesize an oil-soluble poly(3,4-ethylenedioxythiophene) (Oil-PEDOT) as a hole transpo
Photodynamic therapy (PDT),a light triggered therapeutic mode,has been recognized as an attractive treatment for oncotherapy.The phototoxicity to normal tissues during treatment limited the development of PDT owing to the always “on” properties of photose
Electrochromic transition metal oxides (ETMOs) are useful in energy saving devices and smart indicators.Among these ETMO candidates,titanium dioxide (TiO2) is intriguing for its abundance and environmental safety,but the low color efficiency and slow colo
Monomer sequence influences the properties and applications of polymers.Consequently,massive efforts have been made to implement sequence control of polymers.In this work,we developed a computer-aided droplet-flow polymerization based on photo-controlled
An N-heterocyclic carbene (NHC)-catalyzed enantioselective Mannich reaction of the remote 7-carbon of cyclopro-pylcarbaldehydes is disclosed for the first time.Diastereo-and enantiomerically enriched multicyclic δ-lactam compound is afforded as the main p