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目的评价嘉兴市第一医院慢性乙型肝炎住院患者保肝药的用药情况及合理性,为临床合理用药提供参考。方法采用药物利用评价(DUR)和药物利用评估(DUE)法,对该院慢性乙型肝炎住院患者使用保肝药的药物利用指数(DUI)、药物应用情况、治疗过程监测及临床治疗效果进行分析。结果 97例患者共使用保肝药17个品种、21个品规,用药频度前3位的药物分别为多烯磷脂酰胆碱注射液、注射用丁二磺酸腺苷蛋氨酸和注射用复方甘草酸苷。5个品规药物的DUI>1,13个品规的DUI=1,3个品规的DUI<1。一联、二联、三联和四联用药的构成比分别为30.93%(30/97)、46.39%(45/97)、17.53%(17/97)和5.15%(5/97),对应患者肝功能恢复或好转构成比依次为70.00%(21/30)、91.11%(41/45)、82.35%(14/17)和60.00%(3/5)。研究对象均符合病原学分型及临床分期,仅3.09%(3/97)的病例确定了病理学分期。97例患者均有肝功能异常现象,肝功能监测率达100.00%(97/97),93例患者经抗炎保肝等治疗后临床症状得到改善,79例患者肝功能恢复正常。结论联合DUR和DUE法可以更全面地评价慢性乙型肝炎患者的用药情况。该院慢性乙型肝炎住院患者保肝药用药基本合理,二联用药保肝治疗效果最好。
Objective To evaluate the medication status and rationality of hepatoprotective drugs in hospitalized patients with chronic hepatitis B in Jiaxing First Hospital and provide references for clinical rational drug use. Methods The drug utilization index (DUI), drug application, treatment course monitoring and clinical treatment effect of hepatoprotective drugs in hospitalized patients with chronic hepatitis B were analyzed by DUR and DUE. analysis. Results A total of 97 varieties of hepatoprotective drugs were used in 97 patients. Twenty-one products with the first three drug doses were polyene phosphatidylcholine injection, adenosine methionine injection and compound injection Glycyrrhizin. DUI for 5 gauge drugs> DUI for 1, 13 gauge items = DUI <1 for 1 gauge gauge. The constituent ratios of one, two, three and four combined drugs were 30.93% (30/97), 46.39% (45/97), 17.53% (17/97) and 5.15% (5/97), respectively The rates of recovery or improvement of liver function were 70.00% (21/30), 91.11% (41/45), 82.35% (14/17) and 60.00% (3/5) in succession. The subjects were in accordance with the pathogenic classification and clinical stage, only 3.09% (3/97) of the cases to determine the pathological staging. All 97 patients had abnormal liver function. The monitoring rate of liver function was 100.00% (97/97). The clinical symptoms of 93 patients were improved after anti-inflammatory and hepatoprotective treatment, and the liver function of 79 patients returned to normal. Conclusion The combination of DUR and DUE can be more comprehensive evaluation of patients with chronic hepatitis B medication. The hospital chronic hepatitis B inpatients liver medicine is reasonable, two drugs liver treatment the best.