血清阴性脊柱关节病(SPAS)与HLA—B27的密切相关近20年来一直是医学界唯解的谜。随着生物学技术的进步及转基因动物技术的建立,有关这一难题的研究近年又有新的进展。本文就SPAS的发病机制、B27转基因鼠的建立及其在SPAS研究中的应用综述如下。早在1973年Brewerton等发现96％的强直性脊柱炎(AS)患者HLA-B27抗原阳性,而在一般人群仅为4％,以后又发现多种脊 The close correlation between seronegative spondyloarthropathy (SPAS) and HLA-B27 has been the mystery of the medical profession for almost 20 years. With the advancement of biological technology and the establishment of transgenic animal technology, recent progress has been made in the research on this problem. In this paper, the pathogenesis of SPAS, B27 transgenic mice and its application in the study of SPAS are summarized below. As early as 1973, Brewerton et al found that HLA-B27 antigen was positive in 96% of patients with ankylosing spondylitis (AS), compared with only 4% in the general population and later found a variety of ridges