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目的观察孟鲁司特治疗毛细支气管炎临床疗效及对远期喘息复发的影响。方法患儿年龄6个月～2岁,随机分为两组,对照组40例,治疗组41例,两组患儿均给予相同的综合治疗,治疗组在上述常规治疗基础上加用孟鲁司特(顺尔宁)每次4 mg,每晚1次口服,观察两组病儿喘憋缓解、肺部哮鸣音消失时间及痊愈时间,并比较两组疗效,所有患儿均随访6个月,治疗组随访期间每晚继续口服4 mg顺尔宁,观察两组随访期间再次喘息发作次数。结果治疗组总有效率高于对照组,两组比较差异有统计学意义(χ2=7.204,P=0.007<0.05),治疗组在喘憋缓解、肺部哮鸣音消失时间及痊愈时间均少于对照组,两组比较差异有统计学意义,随访期间再次发生喘息情况:对照组13例,发生率13/40,治疗组例4例,发生率4/41,两组比较差异有统计学意义(χ2=5.019,P=0.025<0.05)。结论加用孟鲁司特治疗毛细支气管炎可有效缓解临床症状、缩短痊愈时间并能降低喘息再发率。
Objective To observe the clinical efficacy of montelukast in the treatment of bronchiolitis and its effect on long-term wheezing recurrence. Methods Children aged from 6 months to 2 years were randomly divided into two groups, control group 40 cases, treatment group 41 cases, both groups of children were given the same comprehensive treatment, the treatment group on the basis of the above conventional treatment with the Menlu STI (sirolimus) 4 mg once each night orally, observed two groups of sick children asthma relief, lung wheeze disappeared time and recovery time, and compared the efficacy of both groups, all children were followed up 6 Months, the treatment group continued oral administration of 4 mg of strychnine every night, observe the number of episodes of recurrent wheezing during the two groups were followed up. Results The total effective rate of the treatment group was higher than that of the control group, with significant difference between the two groups (χ2 = 7.204, P = 0.007 <0.05). The relief of asthmatic reaction, the disappearance of lung wheeze and the recovery time were all less In the control group, the difference between the two groups was statistically significant, wheezing occurred again during follow-up: control group of 13 cases, the incidence of 13/40, the treatment group of 4 patients, the incidence of 4/41, the difference between the two groups were statistically significant Significance (χ2 = 5.019, P = 0.025 <0.05). Conclusion Treatment of bronchiolitis with montelukast can effectively relieve clinical symptoms, shorten the recovery time and reduce the recurrence rate of wheezing.