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目的:分析我院药品不良反应事件(ADR)的发生、发展的特点,探讨ADR发生的因素,促进临床安全、合理用药。方法:采用回顾性分析方法,对该院2009年至2013年间收集的177例ADR报告进行分析。结果:177例ADR报告中≤10岁共计92例(52%),21~40岁女性61例(35%);抗菌药物91例(52%),中成药54例(31%);静脉给药150例(85%);主要ADR的临床表现为皮肤及其附件损害137例(77%)。结论:发生ADR的因素涉及患者的年龄、性别、药物的种类、给药途径等,因此需要加强ADR的监测力度,提高临床安全用药意识和水平,确保患者用药安全。
Objective: To analyze the occurrence and development of adverse drug reaction events (ADR) in our hospital, explore the factors that cause ADR, and promote clinical safety and rational use of drugs. METHODS: A retrospective analysis of 177 ADR reports collected in the hospital from 2009 to 2013 was conducted. Results: A total of 92 ADR cases (52%) were reported in 177 ADR patients and 61 (35%) were women aged 21-40 years. Antibiotics were 91 (52%) and 54 (31%) were proprietary Chinese medicines. The drug was given in 150 cases (85%); the main clinical manifestations of ADR were 137 cases (77%) of lesions of the skin and its appendages. Conclusion: The factors that cause ADR are related to patient’s age, gender, type of drug, route of administration, etc. Therefore, we need to strengthen the monitoring of ADR, raise the consciousness and level of clinical safety medication and ensure the safety of patients.