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目的:对蒡芩慢咽宁滴丸中黄芩苷进行了溶出度测定,以考察其内在质量。方法:应用转篮法,以高效液相色谱法(HPLC)测定蒡芩慢咽宁滴丸中黄芩苷的含量为指标,对蒡芩慢咽宁滴丸中黄芩苷进行溶出度测定。结果:以含0.5%十二烷基硫酸钠的蒸馏水溶液为溶剂,转速100 r.min-1,经45 min,溶出度为标示量的70%以上。结论:溶出度测定是控制中药复方制剂内在质量的一种可行的方法。
OBJECTIVE: To determine the dissolution of baicalin in Gushenyaning Dripping Pills to investigate its intrinsic quality. Methods: The method of transfer basket was used to determine the content of baicalin in Gushenyaning Dripping Pill by high performance liquid chromatography (HPLC). The dissolution of baicalin in Gushunyaning Dripping Pill was measured. Results: Using distilled water solution containing 0.5% sodium dodecyl sulphate as solvent, the speed was 100 r.min-1. After 45 min, the dissolution was more than 70% of the indicated amount. Conclusion: Dissolution measurement is a feasible method to control the intrinsic quality of traditional Chinese medicine compound preparations.