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地方性氟中毒是由于长期摄入过量的氟所导致的全身慢性中毒性病变。尤以损伤骨骼和牙齿最为严重,表现为氟骨症和氟斑牙。氟骨症的临床表现和危害极为严重,但由于其发病机制一直未得到彻底阐明,因此迄今尚无有效的治疗方法。大量研究表明,苁蓉具有抗氧化、抗衰老、抗炎及增强免疫功能、调节细胞功能等作用[1-4]。本实验用氟化钠诱发大鼠慢性氟中毒。测定G蛋白的表达。观察苁蓉片对氟中毒大鼠骨组织中G蛋白表达的影响,为防治地方性砷中毒提
Endemic fluorosis is a chronic systemic toxicosis that results from prolonged ingestion of fluoride. Especially the most serious damage to the bones and teeth, manifested as skeletal fluorosis and dental fluorosis. The clinical manifestations and hazards of skeletal fluorosis are extremely serious, but as the pathogenesis of skeletal fluorosis has not been completely elucidated, so far there is no effective treatment. Numerous studies show that Cistanche has anti-oxidation, anti-aging, anti-inflammatory and enhance immune function, regulating cell functions [1-4]. In this experiment, chronic fluoride poisoning was induced by sodium fluoride in rats. G protein expression was measured. To observe the effects of Rongrong Tablet on the expression of G protein in the bone tissue of rats with fluorosis, in order to prevent and cure endemic arsenism