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目的观察亚砷酸(ATO)、全反式维甲酸(ATRA)和化疗联合治疗急性早幼粒细胞白血病(APL)的疗效和副作用。方法对53例初治APL患者分别采用ATO和ATRA联合化疗诱导缓解。结果完全缓解(CR)率为71.6%,部分缓解(PR)率为13.8%。3年复发率为10.5%。结论ATO联合ATRA与化疗治疗APL患者的缓解高,副作用低和复发率低,是临床上治疗急性早幼粒细胞白血病的首选方案。
Objective To observe the efficacy and side effects of combination of arsenious acid (ATO), all-trans retinoic acid (ATRA) and chemotherapy in the treatment of acute promyelocytic leukemia (APL). Methods 53 cases of newly diagnosed APL patients were treated with ATO and ATRA combined with chemotherapy induced remission. Results The complete remission (CR) rate was 71.6% and the partial remission (PR) rate was 13.8%. The 3-year recurrence rate was 10.5%. Conclusion ATO combined with ATRA and chemotherapy in the treatment of APL patients with high remission, low side effects and low recurrence rate is clinically the treatment of acute promyelocytic leukemia preferred program.