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目的研究动脉灌注联合膀胱灌注吡柔比星预防浅表性膀胱癌术后复发的临床意义。方法 32例浅表性膀胱癌患者行经尿道膀胱肿瘤电切术后随机分为两组各16例,分别采用动脉灌注加膀胱灌注吡柔比星和吡柔比星单纯膀胱灌注治疗。结果平均随访23个月。动脉灌注联合膀胱灌注组肿瘤复发1例,单纯吡柔比星灌注组肿瘤复发5例,两组肿瘤复发率差异显著(P<0.05)。结论动脉灌注联合膀胱灌注比柔吡星预防浅表性膀胱癌术后复发疗效较好,副反应少,临床应用安全可靠。
Objective To study the clinical significance of intravesical instillation combined with intravesical instillation of pirarubicin in the prevention of postoperative recurrence of superficial bladder cancer. Methods Thirty-two patients with superficial bladder cancer undergoing transurethral resection of the bladder tumor were randomly divided into two groups (n = 16). Arterial perfusion and intravesical instillation of pirarubicin and pirarubicin were used respectively. The results were followed up for an average of 23 months. One case of tumor recurrence was found in arterial perfusion combined with intravesical instillation group. There were 5 cases of tumor recurrence in pirarubicin-perfusion group. There was significant difference (P <0.05) in tumor recurrence rate between the two groups. Conclusion Arterial perfusion combined with intravesical instillation of doxiflipin in the prevention of postoperative recurrence of superficial bladder cancer has better curative effect, fewer side effects and safe and reliable clinical application.