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目的检测急性冠脉综合征患者发病早期血清中缺血修饰白蛋白(IMA)和超敏C反应蛋白(hs-CRP)的表达量,关注其检测价值及表达的关系,以探讨其临床意义。方法选取本院确诊的103例急性冠脉综合征患者发病早期的血清样本作为观察组,80例正常体检成人血清标本作为对照组,检测二组中IMA和hs-CRP的含量,观察其不同临床特征的意义及表达关系。结果观察组患者血清中hs-CRP和IMA的表达量均明显高于对照组。hs-CRP和IMA的表达均与急性冠脉综合征的分型有关。IMA和hs-CRP的表达呈正相关。结论 hs-CRP和IMA在急性冠脉综合征患者发病早期血清中异常表达,二者可能具有协同作用,联合检测hs-CRP和IMA对早期诊断心肌缺血、判断预后及指导治疗均有重要价值。
Objective To detect the expression of serum IMA and hs-CRP in early stage of acute coronary syndrome (ACS) patients and to investigate the relationship between the expression of IMA and hs-CRP. Methods Serum samples from 103 patients with acute coronary syndrome who were diagnosed as early-onset were selected as the observation group and 80 normal adult serum samples were taken as the control group. The contents of IMA and hs-CRP in the two groups were detected, The significance of the characteristics and the relationship between expression. Results The serum levels of hs-CRP and IMA in observation group were significantly higher than those in control group. The expression of hs-CRP and IMA are related to the type of acute coronary syndrome. IMA and hs-CRP expression was positively correlated. Conclusions hs-CRP and IMA are abnormally expressed in the serum of patients with acute coronary syndromes early onset, and both of them may have synergistic effects. Combined detection of hs-CRP and IMA is of great value in early diagnosis of myocardial ischemia, prognosis and guidance .