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目的:探讨健康女性血清中瘦素水平情况与月经周期的关系。方法:通过放射免疫分析方法检测45例月经正常者中血清瘦素浓度,比较月经期、卵泡期、排卵期及黄体期血清瘦素水平。结果:正常女性血清瘦素水平月经期低于卵泡期,卵泡期低于排卵期,排卵期高于黄体期,黄体期高于月经期,差异均具有显著性(P<0.01)。结论:正常人血清瘦素水平随月经周期呈周期性变化,月经期最低,卵泡期逐渐上升,排卵期最高,黄体期逐渐下降至月经期最低,为临床上瘦素水平定量检测提供了依据。
Objective: To investigate the relationship between serum leptin level and menstrual cycle in healthy women. Methods: Serum leptin levels in 45 cases of normal menstruation were detected by radioimmunoassay. The levels of serum leptin in menstrual period, follicular period, ovulation period and luteal phase were compared. Results: Serum leptin level in normal women was lower than that in follicular phase, follicular phase was lower than ovulation, ovulation was higher than luteal phase, luteal phase was higher than menstruation, the difference was significant (P <0.01). Conclusion: Serum leptin level changes regularly with the menstrual cycle. The menstrual period is the lowest, the follicular phase is gradually increased, the ovulation stage is the highest, the luteal phase is gradually decreased to the lowest at the menstrual period, which provides the basis for the quantitative detection of leptin level in clinic.