近年来,抗生素耐药性日益严重,并且呈现多重耐药现象,已引起临床医生和微生物工作者的高度关注。耐药机制包括染色体基因突变、外膜孔蛋白改变、药物主动外排系统表达亢进和产生灭活酶等。细菌耐药基因通过接合性质粒、转座子、整合型噬菌体、整合子的水平传递等发生传递。现就整合子、插入序列、插入序列共同区域在细菌多重耐药性中的作用予以综述。 In recent years, antibiotic resistance is increasingly serious, and the phenomenon of multi-drug resistance, has attracted great attention of clinicians and microbiological workers. Resistance mechanisms include chromosomal mutations, outer membrane porins change, active drug efflux system expression and produce inactivation enzymes. Bacterial drug resistance genes are transmitted by the binding plasmids, transposons, integrative phage, horizontal transfer of integron, and the like. The roles of integrons, insertions and common regions of insertions in bacterial multidrug resistance are reviewed.