An adaptive closed-loop system for spinal cord injury ( SCI ) repair is designed. It integrates stimulation and recording on 16 pairs of electrodes. Two switches (SAS3T16/SAS1T16X2) fabricated in high-voltage 0. 8 μm process with online re-configurable function are proposed. These two swit-ches are combined with commercial off-the-shelf ( COTS ) electronics to implement the closed-loop implantable system in compact module. The system includes amplifier for recording neural signals, high-voltage stimulator, power transmission device, central processing module and flexible implant-able electrodes. Two customized switches route any electrode to amplifier or stimulator, and nerve stimulation and signal recording are performed through lead wire-driven channels. The entire system is able to operate at up to 28 V, and is a biocompatible package with a volume of 42 mm × 35 mm × 8 mm. This system solves several problems encountered in implantable devices:low flexibility, neg-ative influence of stimulus artifacts on neural detection and low integration of electrodes.