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目的 探讨手术后的恶性骨肿瘤患者经自体瘤苗及TF联合免疫治疗对T4 T8值影响作用 ,研究T4 T8值变化和免疫综合治疗对无瘤生存率的影响。方法 抗人T细胞OKT系统OKT4 、OKT8检测T4 T8值 ,自体瘤苗的转移因子分别皮内注射和皮下注射 ,复查随访无瘤生存率。结果 治疗使无瘤生存率提高 ,使T4 T8值升高 ,而T4 T8值与无瘤生存相关不大。结论 联合免疫治疗提高无瘤生存率 ,可提高整体免疫水平 ,而整体免疫水平无显著变化者也有显著无瘤生存率。提示手术后免疫联合治疗恶性肿瘤的作用主要是特异性抗瘤免疫的激活及敏感性升高 ,这种效应即使在较低的宏观整体免疫水平下也可起作用。
Objective To investigate the effects of autologous tumor vaccine and TF combined immunotherapy on T4 T8 in patients with malignant bone tumor after operation, and to investigate the effect of T4 T8 value and immunotherapy on the tumor-free survival rate. Methods OKT4 and OKT8 of anti-human T cells were used to detect the T4 T8 value. The transfer factors of autologous tumor vaccine were injected intradermally and subcutaneously, respectively. The follow-up no-tumor survival rate was examined. Results The treatment-free survival rate increased, T4 T8 value increased, while T4 T8 value and no tumor-related survival. Conclusions Combined immunotherapy can improve the disease-free survival rate and improve the overall immunity level, but no significant change in the overall immune level also has a significant disease-free survival rate. It is suggested that the combined effect of surgery and immunotherapy on malignant tumors is mainly the activation and sensitivity of specific anti-tumor immunity, which may play a role even at a low level of overall macroimmunity.