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过敏性哮喘病人及动物模型,在吸入抗原后即刻发生的速发性(或早期)哮喘反应(EAR)恢复后,部分病人尚可发生迟发性哮喘反应(LAR),它以起病迟(抗原攻击后6 h左右)、持续时间长(可达数天)、肺功能受损严重和支气管、肺的明显炎症为特征.EAR和LAR均出现者,即为双相反应(DR).LAR具有以下特点:①高发生率,过敏性哮喘病人有50%可发生LAR,在严重哮喘病人中,可达73%.②症状严重,其肺功能受损远较EAR明显而持久,且难以自行恢复,必须依赖药物治疗.③LAR对药物的反应性不同于EAR,对β-肾上腺素受体兴奋药不敏感,而抗炎抗过敏药物的疗效较好.④过敏性哮喘患者接触抗原后,EAR的症状可以很轻甚至不出现,但在离开有过敏原的环境后,却可发生严重的LAR,此时数小时前接触过的抗原易被忽略.由于以上特点,LAR比
In patients and animal models of allergic asthma, a delayed onset of asthmatic response (LAR) may occur in some patients following recovery from immediate (or early) asthma reactions (EAR) immediately after antigen inhalation, Antigens attack about 6 h), long duration (up to several days), severe pulmonary function impairment and bronchial and lung inflammation were characterized by the appearance of bothEAR and LAR, namely biphasic response (DR) .LAR Has the following characteristics: ① high incidence of allergic asthma, 50% of patients can occur LAR, severe asthma patients, up to 73%. ② severe symptoms, their lung function is far more obvious and lasting damage than EAR, and difficult to self Recovery, must rely on drug treatment.③LAR drug reactivity is different from EAR, β-adrenergic receptor agonist is not sensitive, and anti-inflammatory anti-allergic drugs better efficacy.④ allergic asthma patients with antigen, EAR The symptoms can be mild or even non-existent, but serious Alzheimer’s disease can occur after leaving an allergen-free environment and the antigen that was exposed several hours earlier is often overlooked. Because of the above characteristics, the LAR ratio