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The length of telomere in cells is related to the regulation of life span. The activation of telomerase is required for the maintain of telemere. In the pass several years the studies revealed that the activation of telomerase was associated with initiation and progression of tumorigenesis. There was evident that telomerase inhibitors had the inhibitory effect on tumor cells. The regulation of telo-merase activation was probably associated with cyclins. There was evident that telomerase