论文部分内容阅读
目的：观察银杏叶提取物（ EGb）对癫疒间患者认知功能及血浆肌酸激酶脑型同工酶（ CK-BB）含量的影响，探讨EGb对癫疒间发作后认知损害的保护作用及其可能机制。方法符合要求的45例癫疒间患者随机分为治疗组（23例）及对照组（22例），对照组给予丙戊酸钠（VPA）治疗，治疗组在对照组治疗基础上加用银杏叶片。24周后，比较2组治疗效果及2组患者治疗前后认知功能、血浆CK-BB含量的变化。结果治疗后，2组间的疗效比较差异无统计学意义（P＞0．05）；治疗组患者认知评分较对照组明显改善（P＜0．05）；2组CK-BB水平均比治疗前降低（P＜0．05），且治疗组降低更明显（P＜0．05）。结论 EGb能明显改善癫疒间患者的认知功能损害，这一作用可能与其减轻癫疒间发作时脑细胞损伤相关。“,”Objective To observe the effects of extracts of Ginkgo biloba leaf ( EGB) on the cognitive function and possible mechanism in patients with epilepsy .Methods A total of 45 outpatients who were admitted to Donghai Hospital and diagnosed with epilepsy were randomly divided into a treatment group ( VPA+EGb, n=23 ) and a control group (VPA, n=22).Twenty-four weeks later, the cognitive functions before and after treatment were observed according to the Beijing version of Montreal cognitive assessment .The levels of serum CK -BB were examined by the enzyme -linked immunosorbent assay (ELISA).Results There was no significant difference in efficacy between the two groups after treatment.Cognitive function was improved more obviously in VPA +EGb group than that in VPA group (P<0.05). The levels of serum CK-BB in the two groups were lowered after treatment (P<0.05), where more significant reduction was seen the treatment group (P<0.05).Conclusions EGB can remarkably improve the cognitive function of patient with epilepsy which may be associated with its ability to reduce the damage of neurons .