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采用微生物法测定家兔血浆中的活性成分研究头孢羟氨苄赖氨酸盐的药代动力学.实验结果表明,静脉注射羟氨苄头孢菌素在家兔体内的药代动力学符合三室开放模型,其数学表达式分别为C=620.3e~(-26.02)t+78.3e~(-2.07)t+3.91e~(0.224)t.主要药代动力学参数:三相半衰期为t_(1/2)α=0.027±0.014小时,t_(1/2)β=0.34±0.1小时,t_(1/2)γ=0.09±0.65小时;消除速度常数:K_(10)=8.87±3.3小时~(-1);总表观分布容积Vd=7.22±2.9L.
Pharmacokinetics of cefadroxil lysinate was determined by microbiological assay in rabbits plasma.The results showed that the pharmacokinetics of cefazolin in rabbits accorded with the three-compartment open model, The mathematical expressions are as follows: C = 620.3e ~ (-26.02) t + 78.3e ~ (-2.07) t + 3.91e ~ (0.224) t.The main pharmacokinetic parameters are as follows: ) α = 0.027 ± 0.014 h, t_ (1/2) β = 0.34 ± 0.1 h, t_ (1/2) γ = 0.09 ± 0.65 h and the elimination rate constant: K_ (10) = 8.87 ± 3.3 h ~ 1); total apparent distribution volume Vd = 7.22 ± 2.9L.