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[目的]系统评价糖尿病与骨关节炎发病风险的相关性。[方法]计算机检索Pub Med、EMbase、The Cochrane Library、中国知网、维普期刊数据库与万方数据库,搜集糖尿病与骨关节炎发病风险相关性的观察性研究,检索时间均从建库至2016年4月。由2位评价者按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Rev Man 5.3软件进行Meta分析。[结果]最终纳入文献10篇,共23 143例骨关节炎患者。Meta分析结果显示:糖尿病人群的骨关节炎发病风险是正常人群的1.5倍,其差异具有统计学意义[OR=1.50,95%CI[1.10,2.06,P=0.01],经校正年龄、性别、BMI和体力活动等混杂因素的影响后,糖尿病人群的骨关节炎发病风险是正常人群的1.35倍,其差异具有统计学意义[OR=1.35,95%CI(1.10,1.67,P=0.005]。敏感性分析显示本次研究结果稳健性好。[结论]糖尿病与骨关节炎发病具有相关性,糖尿病可增加骨关节炎的发病风险。
[Objective] To systematically evaluate the correlation between diabetes and the incidence of osteoarthritis. [Methods] PubMed, EMbase, The Cochrane Library, CNKI, VIP Journal Database and Wanfang Database were searched by computer. Observe the correlation between the incidence of diabetes and osteoarthritis. The retrieval time was from the database to 2016 April. After two reviewers independently screened the literature for inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies, Meta-analysis was performed using Rev Man 5.3 software. [Results] The final inclusion of 10 articles, a total of 23 143 patients with osteoarthritis. Meta-analysis showed that the incidence of osteoarthritis in diabetic population was 1.5 times of the normal population, with statistical significance (OR = 1.50,95% CI 1.10,2.06, P = 0.01). The adjusted age, sex, BMI and physical activity and other confounding factors, the incidence of osteoarthritis in diabetic population is 1.35 times of the normal population, the difference was statistically significant [OR = 1.35,95% CI (1.10,1.67, P = 0.005]. Sensitivity analysis showed that the results of this study are robust. [Conclusion] The incidence of diabetes is related to the incidence of osteoarthritis. Diabetes can increase the incidence of osteoarthritis.