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目的:研究分析对应激性胃溃疡患者采用奥美拉唑、西咪替丁治疗的临床措施和治疗效果,为其临床治疗提供理论依据。方法:回顾性分析2010年4月-2012年11月期间,我院收治的208例应激性胃溃疡患者的临床资料,按照患者入院治疗的时间顺序,以及临床采用的不同治疗方案,将208例患者分为两组,对照组患者104例,观察组104例。两组患者入院后均给与保护胃黏膜、止血、抗感染等常规治疗,对照组患者在常规治疗的基础上给予西咪替丁治疗,观察组患者在常规治疗的基础上给予奥美拉唑治疗,比较两组患者的临床疗效。结果:对照组患者的平均止血时间为(40.82±7.21)小时,观察组患者为(28.32±4.12)小时。组间比较差异明显,具有统计学意义,(P<0.05);治疗后观察组患者的治疗有效率为94.2%,对照组为69.5%,观察组明显高于对照组,两组比较存在明显差异,差异具有统计学意义(P<0.05)。结论:西咪替丁与奥美拉唑在应激性胃溃疡的治疗中均具有一定的效果,但是奥美拉唑的止血时间较短,疗效更显著,值得临床重视和推广。
OBJECTIVE: To study and analyze the clinical measures and therapeutic effects of omeprazole and cimetidine in patients with stress ulcer and to provide a theoretical basis for their clinical treatment. Methods: The clinical data of 208 patients with stress ulcer admitted to our hospital from April 2010 to November 2012 were retrospectively analyzed. According to the time sequence of patients admitted to hospital and the different clinical treatment plans, 208 The patients were divided into two groups, 104 cases in the control group and 104 cases in the observation group. After admission, both groups were given conventional therapy to protect the gastric mucosa, hemostasis and anti-infection. Patients in the control group were treated with cimetidine on the basis of routine treatment. The patients in the observation group were treated with omeprazole Treatment, the clinical efficacy of two groups were compared. Results: The mean hemostasis time in the control group was (40.82 ± 7.21) hours and in the observation group (28.32 ± 4.12) hours. There was significant difference between the two groups (P <0.05). After treatment, the effective rate of treatment was 94.2% in the observation group and 69.5% in the control group, which was significantly higher in the observation group than in the control group, with significant difference between the two groups , The difference was statistically significant (P <0.05). CONCLUSION: Both cimetidine and omeprazole have certain effects in the treatment of gastric ulcer. However, the omeprazole has a shorter hemostasis time and more effective curative effect, which deserves clinical attention and promotion.