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目的:探究头孢菌素类药物的不良反应和应对策略。方法:选取2014年5月至2015年9月期间该院收治的140例经头孢菌素类药物治疗后出现不良反应的患者,对患者不良反应进行分析,并提出预防性措施。结果:140例患者的主要不良反应包括神经精神系统毒性、胃肠道反应、二重感染、过敏反应、血液及造血系统毒性和肝肾毒性。其中,62例患者不良反应症状严重,61例患者通过及时的治疗和护理后得以治愈,因抢救无效1例死亡。结论:使用头孢菌素类药物进行治疗时,在明确适应症的基础上,积极预防不良反应,减少患者不良反应发生概率,达到安全用药效果,为患者生命健康提供保障。
Objective: To investigate the adverse reactions and coping strategies of cephalosporins. Methods: A total of 140 patients treated with cephalosporins were admitted to our hospital from May 2014 to September 2015. Adverse reactions were analyzed and prophylactic measures were proposed. RESULTS: The major adverse reactions in 140 patients included neuropsychiatric toxicity, gastrointestinal reactions, double infections, allergic reactions, hematologic and hematopoietic toxicities, and hepatorenal toxicity. Among them, 62 patients had serious symptoms of adverse reactions, 61 patients were cured after timely treatment and nursing, and 1 patient died due to ineffective rescue. Conclusion: When using cephalosporins, we can actively prevent adverse reactions, reduce the probability of adverse reactions, achieve the effect of safe medication, and provide the guarantee for the life and health of patients on the basis of definite indications.