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[目的]了解福建省志贺菌感染的病原学特征及药敏特点,为细菌性痢疾的防治和临床合理用药提供依据。[方法]复核鉴定监测点送检的阳性菌株,按《全国细菌性痢疾监测方案》进行系统检测。[结果]4年共复核鉴定菌株115株,有志贺菌77株,其中宋内志贺菌49株,福氏志贺菌28株,分别占检出菌株数的63.6%和36.4%。药敏试验显示,77株志贺菌对头孢噻肟及环丙沙星高度敏感,全部耐药药物为四环素,利福平及复方新诺明。[结论]2005—2008年福建省分离的菌株以宋内志贺菌所占比重较大,其次为福氏志贺菌,其对目前常用的抗菌药物表现一定的耐药性,应引起重视。
[Objective] To understand the etiological characteristics and drug-susceptibility characteristics of Shigella infection in Fujian Province and provide the basis for the prevention and treatment of bacterial dysentery and clinical rational drug use. [Method] The positive strains submitted for inspection at the monitoring sites were reviewed and verified and systematically tested according to the “National Bacterial dysentery monitoring program”. [Result] A total of 115 strains were identified and 77 strains were confirmed to be Shigella in 4 years, of which 49 strains were Shigella sonnei and 28 strains were Shigella flexneri, accounting for 63.6% and 36.4% of the total isolates. Susceptibility test showed that 77 strains of Shigella were highly sensitive to cefotaxime and ciprofloxacin, and all the drug-resistant drugs were tetracycline, rifampicin and cotrimoxazole. [Conclusion] The strains isolated from Fujian Province in 2005-2008 accounted for the largest proportion of Shigella sonnei, followed by Shigella flexneri, which showed some resistance to commonly used antibiotics, which should be paid more attention.