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以３种动物模型研究了血脂康的降血脂作用。将２５％酪蛋白加入家兔基础饲料中，６０ｄ后血清ＴＣ从１．８１ｍｍｏｌ／Ｌ升至７．５１ｍｍｏｌ／Ｌ，则内源性高胆固醇血症模型建立；血脂康０．４，０．８ｇ·ｋｇ￣（－１）·ｄ￣（－１）治疗性给药３０ｄ后，有显著降低血清ＴＣ浓度和ＴＣ／ＨＤＬ－Ｃ比值（０．８ｇ．ｋｇ￣（－１）·ｄ￣（－１））的作用（Ｐ＜０．０５）。将０．５％胆固醇，１５％蛋黄粉，５％猪油加入家兔基础饲料中，可形成外源性高脂血症模型；同时预防性ｐｏ血脂康０．８９．ｋｇ￣（－１）·ｄ￣（－１）后，服药家兔血清ＴＣ、ＴＧ浓度和ＴＣ／ＨＤＬ－Ｃ比值明显降低（Ｐ＜０．０５），且有抑制主动脉粥样硬化斑块形成和脂质在肝脏沉积的作用。将１％胆固醇，１４％猪油，６％豆油加入鹌鹑基础饲料中，２周后可形成外源性高脂血症模型；同时预防性ｐｏ血脂康０．１，０．２，０．４ｇ．ｋｇ￣（－１）·ｄ￣（－１）后，可显著降低血清ＴＣ、ＴＧ（Ｐ＜０．０５或Ｐ＜０．０１）的浓度。此结果证实了血脂康在降血脂及预防动脉粥样硬化方面的药理作用。
The effects of Xuezhikang on the hypolipidemic effects were studied in three animal models. After adding 25% casein into rabbit basic diet, serum TC increased from 1.81mmol / L to 7.51mmol / L after 60 days, then the model of endogenous hypercholesterolemia was established. Xuezhikang 0.4,0.8g Kg · (-1) · d ~ (-1) after 30 days of therapeutic administration, there was a significant decrease in serum TC concentration and TC / HDL-C ratio (0.8g.kg ~ (-1) · d ~ (- 1)) (P <0.05). 0.5% cholesterol, 15% egg yolk powder, 5% lard added to the rabbit basic feed, can form exogenous hyperlipidemia model; at the same time preventive po Xuezhikou 0.89. kg ~ (-1) · d ~ (-1), the serum TC, TG concentration and TC / HDL-C ratio in the treated rabbits decreased significantly (P <0.05), and the inhibition of aortic atherosclerotic plaque Formation and lipid deposition in the liver. Add 1% cholesterol, 14% lard, 6% soybean oil to the quail basal diet, 2 weeks after the formation of exogenous hyperlipidemia model; the same time preventive po Xuezhikang 0.1,0.2,0.4 g . kg ~ (-1) · d ~ (-1) significantly decreased the levels of serum TC and TG (P <0.05 or P <0.01). This result confirms Xuezhikang lipid-lowering and prevention of atherosclerosis pharmacological effects.