采用Ph3PAuNTf2作为催化剂,8-甲基喹啉氮氧化物为氧化剂,甲基磺酸为添加酸,金催化氧化末端炔烃与乙酸分子反应,室温下高效合成了一系列α-乙酰氧基甲基酮化合物.考察了氧化剂、催化剂结构、催化剂用量等因素对反应的影响,确定了最优反应条件,最高收率为90%.提出了α-羰基金卡宾对乙酸分子O—H键的卡宾反应机理.该方法具有操作简单、条件温和、产率高等特点,为含有α-乙酰氧基甲基酮结构的化合物合成提供了一条新的途径. Using Ph3PAuNTf2 as catalyst, 8-methylquinoline oxynitride as oxidant, methanesulfonic acid as additive acid, gold catalyzed oxidation of terminal alkyne with acetic acid molecules, a series of α-acetoxymethyl Ketone compounds. The effects of oxidant, catalyst structure, amount of catalyst and other factors on the reaction were investigated. The optimal reaction conditions were determined and the highest yield was 90% .The carbene reaction of α-carbonyl gold carbene on the O-H bond of acetic acid The method has the advantages of simple operation, mild conditions and high yield, and provides a new way for the synthesis of compounds containing α-acetoxymethyl ketone structure.