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采用数字化冠脉造影图像，测量由内皮依赖性扩张物质（ｓｕｂｓｔａｎｃｅＰ，物质Ｐ）引起的冠脉直径变化，评价血管内皮功能。３５例受试者，９例冠脉造影正常者为对照组，２６例冠脉造影明显改变者为冠心病组。受试者在行诊断性冠脉造影术后，先、后分别在冠状动脉内注入生理盐水和物质Ｐ（２５ｐｍｏｌ／ｍｉｎ），每次注入前、后的造影结果，通过计算机数字化图像分析系统测量冠状动脉直径变化。结果显示，物质Ｐ对正常的冠状动脉有明显的扩张作用，而动脉粥样硬化病变的血管对物质Ｐ的反应明显减弱。提示，冠脉造影有病变的患者，血管内皮依赖性扩张功能损伤
Digital coronary angiography images were used to measure changes in coronary diameter caused by endothelium-dependent dilation substance (substance P) to assess endothelial function. 35 subjects, 9 cases of normal coronary angiography as control group, 26 cases of coronary angiography was significantly changed coronary heart disease group. Subjects underwent diagnostic coronary angiography, before and after the injection of normal saline and substance P (25 pmol / min) in the coronary arteries, before and after each injection of angiography results were measured by a computerized digital image analysis system Coronary artery diameter changes. The results showed that the substance P on the normal coronary artery has a significant expansion, and atherosclerotic lesions of the blood vessels on the substance P response was significantly weakened. Tip, coronary angiography in patients with lesions, endothelium-dependent dilation function damage