论文部分内容阅读
目的 研究纳络酮(NAL)对家兔急性酒精中毒后外伤性脑水肿的治疗作用。方法 经胃管注入乙醇致家兔急性酒精中毒,自由落体打击法制作外伤性脑水肿模型,并在伤后30min静注NAL 2mg/kg,以后每隔60min重复注射一次。测定伤后4h脑组织超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)含量及脑组织含水量,并与对照组比较。结果 治疗组与对照组比较,SOD活性增加(P<0.01),LPO含量降低(P<0.01),脑组织含水量减少(P<0.05)。结论 NAL有抗自由基作用并可减轻兔急性酒精中毒后外伤性脑水肿。
Objective To study the therapeutic effect of naloxone on traumatic brain edema after acute alcoholism in rabbits. Methods Acute alcoholism induced by alcohol in rabbits was induced by alcohol in gastric tube. The model of traumatic cerebral edema was established by free-fall attack. NAL 2 mg / kg was intravenously injected 30 min after the injury, and then repeated every 60 minutes. The activity of superoxide dismutase (SOD), the content of lipid peroxide (LPO) and the water content of brain tissue in brain tissue were determined 4 h after injury and compared with the control group. Results Compared with the control group, the SOD activity increased (P <0.01), the LPO content decreased (P <0.01), and the brain water content decreased (P <0.05). Conclusion NAL has anti-free radical effect and can reduce traumatic brain edema after acute alcoholism in rabbits.