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目的探讨左卡尼丁治疗维持性血液透析致营养不良的临床疗效。方法选取沧州市中心医院2016年1—9月收治的维持性血液透析致营养不良患者100例,采用随机数字表法分为对照组和试验组,各50例。患者均给予常规血液透析,对照组患者给予α酮酸片治疗,试验组患者给予左卡尼丁治疗。比较两组患者治疗前后改良主观营养评价法(MQSGA)评分、清蛋白(Alb)、前清蛋白(PA)、血红蛋白(Hb)、血肌酐(Scr)及主观综合性营养评分量表(SGA)评分。结果治疗前,两组患者MQSGA评分、Alb、PA、Hb、Scr比较,差异无统计学意义(P>0.05);治疗后,两组患者Scr比较,差异无统计学意义(P>0.05),试验组患者MQSGA评分低于对照组,Alb、PA、Hb高于对照组(P<0.05)。治疗前,两组患者SGA评分比较,差异无统计学意义(P>0.05);治疗后,试验组患者SGA评分高于对照组(P<0.05)。结论采用左卡尼丁可有效改善维持性血液透析患者营养不良情况,对提高患者的生活质量具有重要作用。
Objective To investigate the clinical effect of left carnitine on malnutrition caused by maintenance hemodialysis. Methods 100 cases of malnourished patients who underwent maintenance hemodialysis from January to September in 2016 in Central Hospital of Cangzhou were selected and randomly divided into control group and trial group with 50 cases in each group. Patients were given routine hemodialysis, patients in the control group were treated with alpha-ketoacid tablets, and patients in the test group were treated with levarnucin. The scores of modified subjective nutritional assessment (MQSGA), albumin (Alb), prealbumin (PA), hemoglobin (Hb), serum creatinine (Scr) and subjective comprehensive nutritional score (SGA) were compared between the two groups before and after treatment. score. Results Before treatment, there was no significant difference in MQSGA score, Alb, PA, Hb and Scr between the two groups (P> 0.05). After treatment, there was no significant difference in Scr between the two groups (P> 0.05) The scores of MQSGA in trial group were lower than those in control group, but Alb, PA and Hb were higher than those in control group (P <0.05). Before treatment, there was no significant difference in SGA scores between the two groups (P> 0.05). After treatment, the SGA scores in the experimental group were significantly higher than those in the control group (P <0.05). Conclusion LAC is effective in improving the malnutrition in maintenance hemodialysis patients and plays an important role in improving patients’ quality of life.