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自从介绍用皮质类固醇治疗肾病综合征以来,29年过去了,对儿童的疗效似可确信,然而类固醇治疗对成年人是否有利还不清楚。此外,此种治疗的危险性,成年人也大于儿童。本文报道隔日短疗程强的松治疗膜性肾病的效果。72例(男42,女30)病人,年龄16～65岁。病者过去从未用过激素或免疫抑制剂,无肾功能不全,活检时发现为膜性肾病。在一多中心研究中,这些病人随机分为强的松组或安慰组,隔日用强的松或安慰剂,
Since the introduction of nephrotic syndrome with corticosteroids, 29 years have passed and the efficacy in children seems plausible, but it is unclear whether steroid therapy is beneficial to adults. In addition, the risk of such treatment, adults are also greater than children. This article reports the effect of a short course of prednisone every other day on membranous nephropathy. 72 (male 42, female 30) patients, aged 16 to 65 years. The patient had never used hormones or immunosuppressive agents in the past, no renal insufficiency, membranous nephropathy was found on biopsy. In a multicentre study, these patients were randomly assigned to either prednisone or placebo, with prednisone or placebo on alternate days,