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目的：探讨Ｐ１６ 蛋白表达与喉癌的关系。方法：采用Ｓ－ Ｐ免疫组化方法对５０ 例喉鳞癌标本及作为对照的１０ 例声带息肉标本进行检测。结果：５０ 例喉癌组织中有３１ 例表达阳性（ 阳性率６２．０％ ） ，１０ 例声带息肉组织全部为阳性（ 阳性率１００％ ） ，Ｐ１６ 蛋白表达与喉癌有无颈淋巴结转移无关，而与喉癌的组织分化程度、临床分期显著相关。结论：Ｐ１６ 蛋白的表达在喉癌的发生发展中起一定作用，并可作为判断喉癌预后的一个参考指标。
Objective: To investigate the relationship between P16 protein expression and laryngeal cancer. Methods: S-P immunohistochemistry was used to detect 50 specimens of laryngeal squamous cell carcinoma and 10 specimens of vocal cord polyps as controls. Results: Among the 50 cases of laryngeal carcinoma, 31 cases were positive (positive rate 62.0%). All 10 cases of vocal cord polyps were positive (100% positive rate). The expression of P16 protein was not related to cervical lymph node metastasis in laryngeal cancer. It was significantly associated with the degree of tissue differentiation and clinical stage of laryngeal cancer. Conclusion: The expression of P16 protein plays a role in the occurrence and development of laryngeal cancer, and it can be used as a reference index to predict the prognosis of laryngeal cancer.