Ⅱ类分泌型磷脂酶A2 (sPLA2 Ⅱ )在急性肺损伤 (ALI)发病过程中 ,起了重要作用。sPLA2 II在体内主要的细胞来源是巨噬细胞 ,在肺内的主要靶点是表面活性物质。sPLA2 Ⅱ在体内与表面活性物质及其代谢产物花生四烯酸、前列腺素之间相互作用 ,导致ALI时的恶性循环。sPLA2 II通过细胞外信号调节激酶 (ERK)和核因子 κB(NF κB)途径刺激巨噬细胞内诱生型NO合酶 (iNOS)的表达 ,损伤肺组织。抗sPLA2 II策略为ALI的临床治疗提供了新的思路 Class II secreted phospholipase A2 (sPLA2 Ⅱ) plays an important role in the pathogenesis of acute lung injury (ALI). The main cellular source of sPLA2 II in vivo is macrophages, and the primary target in the lung is the surfactant. sPLA2 Ⅱ in the body and surfactant and its metabolites arachidonic acid, prostaglandin interaction between, leading to a vicious cycle of ALI. sPLA2 II stimulated the expression of inducible NO synthase (iNOS) in macrophages via the extracellular signal-regulated kinase (ERK) and nuclear factor κB (NF-κB) pathways and damaged the lung tissue. Anti-sPLA2 II strategy for the clinical treatment of ALI provides a new way of thinking