本文主要探讨氟氯西林(flucloxacillin)引起肝损害的危险性.氟氯西林是一种半合成异(口恶)唑青霉素,是耐青霉素G葡萄球菌感染一线治疗药物.在严重葡萄球菌感染时,胃肠外给予氯唑西林和氟氯西林的疗效相似.然而,氟氯西林胃肠吸收好,可供口服,且血药浓度比氯唑西林高,维持时间更长. This article focuses on the risk of hepatic damage caused by flucloxacillin, a semi-synthetic oxacillin that is the first-line treatment of penicillin-resistant Staphylococcal Infection, The efficacy of parenteral cloxacillin and flucloxacillin was similar, however, flucloxacillin was well absorbed by the gastrointestinal tract and was orally administered at a higher blood concentration than cloxacillin for a longer period of time.