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目的 探讨血清C -反应蛋白 (CRP)测定对社区获得性肺炎 (CAP)的诊断价值。方法 将 70例CAP患者按血白细胞(WBC)计数 10 0× 10 9/L为界分为A、B两组 ,另设 80例上呼吸道感染患者为对照组 (C组 ) ,采用金标定量检测法测定血清CRP含量。结果 血CRP含量 :A组 [( 12 3 71± 5 6 95 )mg/L]、B组 [( 96 2 8± 45 0 9)mg/L]显著高于C组 [( 11 40± 3 71mg/L) ] ,P <0 0 1,而A组又高于B组 ,P <0 0 1。血WBC计数 :A组 [( 13 . 72± 4 13 )× 10 9/L]高于B组 [( 7 17± 1 3 7)× 10 9/L] ,P <0 0 1,B组与C组[( 6 3 6± 1 61)× 10 9/L) ]无显著差异 ,P >0 0 5。分别将血CRP含量≥ 2 5mg/L、血WBC≥ 10 0× 10 9/L和血中性粒细胞比例≥ 80 %定为CAP诊断阳性标准 ,则敏感性分别为 10 0 %、48 6%和 40 %,特异性分别为 95 %、92 5 %和 95 %。血CRP对CAP诊断敏感性高于血WBC计数和中性粒细胞比例 ,P <0 0 1。结论 检测血CRP水平有助于CAP ,尤其是血WBC不高CAP的诊断和疗效评价
Objective To investigate the diagnostic value of serum C - reactive protein (CRP) in community - acquired pneumonia (CAP). Methods Seventy patients with CAP were divided into A and B groups according to the WBC counts of 10 × 10 9 / L. Another 80 patients with upper respiratory tract infection were selected as the control group (C group) Detection of serum CRP levels. Results Blood CRP levels were significantly higher in group A than those in group C ((12 3 71 ± 5 6 95) mg / L] and group B [(96 2 8 ± 45 0 9) mg / L] / L)], P <0 0 1, while group A was higher than group B, P <0.01. Blood WBC counts were significantly higher in group A than those in group B [(13.72 ± 4 13) × 10 9 / L] [(17 17 ± 13 7) × 10 9 / L], P < There was no significant difference in group C [(636 ± 1 61) × 10 9 / L), P> 0.05. The blood levels of CRP≥25mg / L, blood WBC≥10 × 109 / L and blood neutrophil ratio≥80%, respectively, were set as the positive diagnostic criteria for CAP. The sensitivity was 100% and 48%, respectively And 40% with specificity of 95%, 92 5% and 95%, respectively. The sensitivity of blood CRP to CAP diagnosis was higher than that of blood WBC count and neutrophil count, P <0.01. Conclusion The detection of blood CRP is helpful to the diagnosis and evaluation of CAP, especially the low blood WBC