论文部分内容阅读
背景与目的:肥胖被证实为增加结直肠癌的重要因素。有研究表明,无论对于男性还是女性,体质指数(body mass index,BMI)都与结肠癌的发病率有密切关系。因此,本研究探讨BMI与我国结肠癌发病的关系,为结肠癌的预防提供参考。方法:用病例-对照研究方法分析707例首次确诊的结肠癌患者和709名健康人的BMI情况,比较两组人群BMI的情况。结果:首次确诊的结肠癌患者平均BMI为(24.52±4.56)kg/m2,健康对照人群平均BMI为(23.75±3.14)kg/m2,结肠癌患者的BMI明显高于健康对照人群(t=-3.72,P<0.001)。根据性别和年龄的不同进行分组后,可以看出结肠癌患者的BMI比健康对照组高。logistic回归分析,BMI的升高是结肠癌发生的危险因素,OR值为1.059(95%CI,1.029～1.090)。结论:汉族人结肠癌的发生与BMI有关。
Background and Objective: Obesity has been shown to be an important factor in increasing colorectal cancer. Studies have shown that body mass index (BMI) is closely related to the incidence of colon cancer in both males and females. Therefore, this study explored the relationship between BMI and the incidence of colon cancer in our country, providing a reference for the prevention of colon cancer. Methods: A case-control study was conducted to analyze the BMI of 707 first diagnosed colon cancer patients and 709 healthy individuals. The BMI of the two groups was compared. Results: The mean BMI was (24.52 ± 4.56) kg / m2 in the first confirmed colon cancer patients and (23.75 ± 3.14) kg / m2 in the healthy control subjects, and the BMI in the colon cancer patients was significantly higher than that in the healthy controls (t = 3.72, P <0.001). When grouped by gender and age, one can see that BMI in colon cancer patients is higher than in healthy controls. Logistic regression analysis showed that the increase of BMI was the risk factor of colon cancer. The OR value was 1.059 (95% CI, 1.029-1.090). Conclusion: The incidence of colon cancer in Han people is related to BMI.