【摘 要】
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Objective: To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis. Methods: The S-P immunohistochemical me
【机 构】
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Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;
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Objective: To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis. Methods: The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic tumors, and microvessel density (MVD) was detected by CD31 staining. Results: In astrocytic tumors with Ⅰ,Ⅱ,Ⅲ and Ⅳ grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respeclively, those of Pyk2 were 40.00%, 60.00%, 77.76% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated positively with VEGF expression and MVD. Conclusion: FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.
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