论文部分内容阅读
肝X受体是孤核受体超家族成员之一，其天然配体为氧化固醇，越来越多的证据表明，肝X受体可能对心脏具有直接的有益作用。心力衰竭是心血管疾病的终末表现，且随着老龄化的发展，发病率逐年增加。研究发现肝X受体在动脉粥样硬化、高血压、糖尿病、心肌肥厚、心肌纤维化等发展中起着重要作用，这使得肝X受体成为心力衰竭治疗的理想靶点。“,”Liver X receptors are members of the nuclear receptor superfamily , which their natural ligands are oxysterols .More and more studies suggest that liver X receptors may have a direct beneficial effect on the heart .Heart failure is the terminal progression of cardio-vascular disease and its prevalence is increasing in our aging society .Research has outlined the importance of liver X receptors signaling pathways in the development of atherosclerosis , hypertension , diabetes , cardiomyocyte hypertrophy and cardiac fibrosis .These observations make liver X receptors an attractive agent for therapeutic treatments of heart failure .