α-胎儿蛋白(AFP)是来自胎儿肝脏的糖蛋白,在胎儿血清和羊水中浓度很高.母亲血清中AFP浓度在妊娠中期增高,分娩后迅速降低到正常成人水平.已证实AFP在体内、外对体液和细胞免疫有抑制作用,并参与妊娠时的免疫调节,在保护胎儿免受排斥中起作用.作者证实人AFP可抑制实验性重症肌无力(EAMG)和实验性变应性脑脊髓炎(EAE)的发展.还观察到AFP既能抑制重症肌无力又能抑制 Alpha-fetoprotein (AFP), a glycoprotein from the fetal liver, is highly concentrated in fetal serum and amniotic fluid, and the AFP concentration in maternal serum is elevated during the second trimester of pregnancy and rapidly decreases to normal adult levels after delivery. AFP has been shown to be active in the body, Inhibition of humoral and cellular immunity in vitro, and participation in immunomodulation during pregnancy, play a role in protecting the fetus from rejection. The authors demonstrate that human AFP can inhibit both experimental myasthenia gravis (EAMG) and experimental allergic encephalomyelitis Inflammation (EAE) .AFP was also observed both inhibit myasthenia gravis and inhibit