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目的探讨娱乐性体力活动与中老年子宫肌瘤(UL)危险性之间的关系。方法采用以医院为基础的病例对照研究方法,选择35~62岁UL患者353例(UL组),同时选择同期入住相同医院按年龄进行频数匹配的353例非UL患者为对照组。采用调查表对研究对象进行调查,内容包括:人口学特征、身体测量值、生活方式以及疾病既往史等。还采用国际体力活动调查表(IPAQ)对研究对象的体力活动情况进行调查。应用多因素Logistic回归分析估计娱乐性体力活动与UL关联的比值比(OR)及其相应的95%可信区间(CI)。结果 UL组产次≥2的比例明显低于对照组,UL组的高血压和糖尿病患者均高于对照组。调整多种潜在性混杂因素后,与MET为最低四分位数的对照相比较,MET为第二、三个四分位数的病例发生UL的危险性均降低。能量消耗为第二、三个四分位数的病例发生UL的危险性显著地低于能量消耗为最低四分位数的对照。结论进行丰富的娱乐性体力活动,可能有助于预防UL。
Objective To investigate the relationship between recreational physical activity and the risk of uterine fibroids (UL) in middle-aged and elderly people. Methods A case-control study based on hospital was conducted. 353 UL patients aged 35-62 years (UL group) were selected. 353 non-UL patients with the same age who were hospitalized in the same hospital during the same period were selected as the control group. A questionnaire was used to investigate subjects, including demographic characteristics, body measurements, lifestyle, and past medical history. The International Physical Fitness Questionnaire (IPAQ) was also used to investigate the physical activity of the subjects. Multivariate logistic regression analysis was used to estimate odds ratio (OR) and its corresponding 95% confidence interval (CI) between recreational physical activity and UL. Results The proportion of patients with UL group ≥2 was significantly lower than that of the control group. The patients with hypertension and diabetes in the UL group were higher than those in the control group. After adjusting for a variety of potential confounders, the risk of developing UL was lower for METs than for those with METs as the lowest quartile, with METs in the second and third quartile. In the second and third quartile of cases, the risk of developing UL was significantly lower than the control with the lowest quartile of energy expenditure. Conclusion Enriching recreational physical activities may help prevent UL.