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目的探讨肥胖对排卵正常患者IVF-ET促排卵过程中卵巢反应性的影响。方法回顾性分析首都医科大学附属北京妇产医院2009年1月~2015年12月接受IVF-ET的、排卵正常的943例患者的所有统计学资料。按照BMI将受试者分为四组:低体重组(BMI<18.5kg/m2),正常体重组(BMI在18.5~23.9kg/m2之间),超重组(BMI在24.0~27.9kg/m2之间)和肥胖组(BMI≥28.0kg/m2),并比较各组间基线数据和卵巢反应性数据。结果 943例排卵正常患者中,低体重组患者70例,正常体重组640例,超重组192例,肥胖组41例。四组间比较,结果提示不孕年限和用药量组间差异存在统计学差异(P<0.05);组间两两比较,可见肥胖组不孕年限明显高于低体重组、正常体重组和超重组,肥胖组的用药量明显高于低体重组和正常体重组,组间差异均存在统计学意义(P<0.05)。b FSH、用药天数、获卵数和受精率组间差异均未见统计学意义(P>0.05)。结论对于排卵正常的病人而言,肥胖使其促排卵过程中用药量增加,但对其卵巢反应性没有明显影响。
Objective To investigate the effect of obesity on ovarian response during IVF-ET ovulation induction in normal ovulation patients. Methods A retrospective analysis of all the statistical data of 943 patients with IVF-ET who had normal ovulation from Beijing Obstetrics and Gynecology Hospital of Capital Medical University from January 2009 to December 2015 was retrospectively analyzed. Subjects were divided into four groups according to BMI: low body weight (BMI <18.5 kg / m 2), normal body weight (BMI 18.5-23.9 kg / m 2) and overweight (BMI 24.0-27.9 kg / m 2 ) And obesity group (BMI≥28.0kg / m2), and compared baseline data and ovarian response data between groups. Results Among the 943 normal ovulation patients, 70 were in low body weight group, 640 in normal body weight group, 192 in overweight group and 41 in obesity group. The results of the four groups showed that there was a statistically significant difference in the duration of infertility and the dosage (P <0.05). Comparing the two groups, the duration of infertility in the obese group was significantly higher than that in the low-weight group, normal weight group and super-weight group The dosage of recombinant, obese group was significantly higher than that of the low-weight group and the normal-weight group, there were significant differences between the two groups (P <0.05). b FSH, medication days, the number of oocytes retrieved and fertilization rate between the two groups were not statistically significant (P> 0.05). Conclusion For patients with normal ovulation, obesity increases the amount of drugs used during ovulation induction, but has no significant effect on ovarian response.